Imura Akihiro
Foundation for Biomedical Research and Innovation, Japan.
Clin Calcium. 2013 Oct;23(10):1476-82.
Recent understandings of phosphate regulation have, at least in part, depended upon the findings of fibroblast growth factor (FGF) 23, the hormone specific for phosphate regulation. Moreover, FGF23 would be the most important marker for prognosis in chronic kidney disease (CKD) . On the other hand, Klotho was firstly developed as a responsible gene for senescence. Although the role of Klotho has been so far established as a co-receptor for FGF23 in mineral metabolism, Klotho would play rather various roles than FGF23 signaling. Thus Klotho is not necessarily equivalent to FGF23. Further studies for both Klotho and FGF23 will elucidate to understand mineral homeostasis.
近期对磷酸盐调节的认识至少部分依赖于成纤维细胞生长因子（FGF）23的研究结果，FGF23是一种特定的磷酸盐调节激素。此外，FGF23可能是慢性肾脏病（CKD）预后的最重要标志物。另一方面，klotho最初是作为衰老的相关基因被发现的。尽管目前已知klotho在矿物质代谢中作为FGF23的共受体发挥作用，但klotho可能比FGF23信号传导发挥更多样化的作用。因此，klotho不一定等同于FGF23。对klotho和FGF23的进一步研究将有助于阐明矿物质稳态。
