Ramabadran K, Bansinath M
Clinical Research Department #426, Abbott Laboratories, Abbott Park, IL 60064-3500.
Int J Clin Pharmacol Ther Toxicol. 1990 Feb;28(2):47-62.
The discovery of the existence of opiate receptors in 1973 and of the endogenous opioid peptides, leu and met-enkephalin in 1975, has elicited an extensive search for the physiological and pathophysiological role of opioid systems. The role of endogenous opioid peptides in pathophysiology and pharmacotherapy of epilepsies is one of the most exciting and stimulating new areas in the study of the endogenous opioid systems. The present understanding in this area is fragmentary and hence further attempts to elucidate the opioid function in epilepsies is of fundamental importance. The aim of this review is to summarize some of the recent findings on the link between the endogenous opioid peptides and epilepsy.
1973年阿片受体的存在以及1975年内源性阿片肽亮氨酸脑啡肽和甲硫氨酸脑啡肽的发现，引发了对阿片系统生理和病理生理作用的广泛探索。内源性阿片肽在癫痫的病理生理和药物治疗中的作用是内源性阿片系统研究中最令人兴奋和最具启发性的新领域之一。目前该领域的认识尚不完整，因此进一步阐明阿片类物质在癫痫中的作用至关重要。本综述的目的是总结内源性阿片肽与癫痫之间联系的一些最新研究结果。
