University of California, Irvine, Orange, CA.
Pain Physician. 2013 Sep-Oct;16(5):E627-30.
Intrathecal drug delivery systems are becoming an increasingly common modality used by physicians to treat patients. Specifically, chronic spasticity secondary to multiple sclerosis (MS) may be treated with intrathecal baclofen (ITB) therapy when oral antispasmodics do not provide adequate relief. ITB therapy is effective, localizes drug delivery, and does not have the same degree of intolerable systemic effects often seen with oral and parenteral medications. As the use of intrathecal drug delivery systems has become more common, so has the incidence of adverse events. ITB administration requires the surgical implantation of indwelling catheters and a pump reservoir. Although this therapy is useful in treating spasticity, risks unique to intrathecal drug delivery systems include medication dosing errors, pump malfunction, infection, and catheter breakage or dislocation. To our knowledge intrathecal pump catheter migration into the spinal cord is a very rare complication with only 2 such complications reported. We present a case of an intrathecal baclofen pump catheter that was initially believed to have migrated into the spinal cord and the innovative use of cinefluoroscopy and digital subtraction used to identify catheter placement. Moreover, after confirmation of the catheter position within the spinal cord on magnetic resonance imaging (MRI) our team elected to perform a laminectomy, which demonstrated that the catheter was not in the spinal cord but was surrounded by arachnoid adhesions. We hope our efforts will provide the clinician insight into the common difficulties that arise and how best to troubleshoot them to serve this specific patient population and prevent potentially life-threatening complications.
鞘内药物递送系统正成为医生治疗患者的一种越来越常见的方式。具体来说,多发性硬化症(MS)引起的慢性痉挛性疾病可以通过鞘内巴氯芬(ITB)治疗,如果口服抗痉挛药物不能提供足够的缓解。ITB 治疗有效,药物定位,并且没有口服和肠胃外药物常见的不可耐受的全身效应。随着鞘内药物递送系统的使用越来越普遍,不良事件的发生率也有所增加。ITB 给药需要手术植入留置导管和泵储液器。虽然这种治疗方法对治疗痉挛很有用,但鞘内药物递送系统特有的风险包括药物剂量错误、泵故障、感染以及导管断裂或脱位。据我们所知,鞘内泵导管迁移到脊髓是一种非常罕见的并发症,只有 2 例这样的并发症报告。我们报告了一例 ITB 泵导管最初被认为已迁移到脊髓的病例,并创新性地使用电影透视和数字减影来识别导管位置。此外,在 MRI 确认导管在脊髓内的位置后,我们的团队决定进行椎板切除术,结果表明导管不在脊髓内,而是被蛛网膜粘连所包围。我们希望我们的努力能为临床医生提供对常见困难的深入了解,并提供最佳的故障排除方法,以服务于这一特定患者群体并预防潜在的危及生命的并发症。