Rezaeian Shahab, Poorolajal Jalal, Moghimbegi Abbas, Esmailnasab Nader
Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
J Res Health Sci. 2013 Sep 17;13(2):151-6.
The aim of this study was to investigate the relationship between congenital hypothyroidism and several variables using two different adjustment methods.
This matched case-control study was conducted in Hamadan Province, the west of Iran, in 2012 enrolling neonates born between 2005 and 2011 and covered by screening program for congenital hypothyroidism. The neonates with TSH titer more than 10 mU/l or T4 titer less than 6.4 μg/dl were considered as cases. Each case was individually matched for birth place and year with four neonates with normal TSH and T4 titers as controls. The data were analyzed using two different approaches including propensity score and multiple conditional logistic regression model.
Of 1313 enrolled neonates, 277 (159 girls) were cases and 1036 (531 girls) were controls. The most important prognostic factors which had significant effect on congenital hypothyroidism included twin, birth season, maturity, jaundice at birth, birth weight, age at pregnancy, maternal anemia and goiter, gestational age, delivery type, father's education and smoking status, and consanguinity. The associations reported by logistic regression were stronger that of than propensity score analysis in most items, although the differences were not statistically significant.
We addressed the effect of numerous potential risk factors on congenital hypothyroiditis and the impact of these factors on the disease occurrence. However, future prospective studies are needed to test these findings and hypothesis and to investigate the true effect of these potential risk factors on congenital hypothyroiditis.
本研究旨在使用两种不同的调整方法来探究先天性甲状腺功能减退症与多个变量之间的关系。
这项匹配病例对照研究于2012年在伊朗西部的哈马丹省进行，纳入2005年至2011年出生且参加先天性甲状腺功能减退症筛查项目的新生儿。促甲状腺激素（TSH）滴度高于10 mU/l或甲状腺素（T4）滴度低于6.4 μg/dl的新生儿被视为病例。每个病例按照出生地点和年份与四名TSH和T4滴度正常的新生儿进行个体匹配，作为对照。数据使用两种不同的方法进行分析，包括倾向得分法和多重条件逻辑回归模型。
在1313名纳入研究的新生儿中，277例（159名女孩）为病例，1036例（531名女孩）为对照。对先天性甲状腺功能减退症有显著影响的最重要预后因素包括双胞胎、出生季节、成熟度、出生时黄疸、出生体重、妊娠年龄、母亲贫血和甲状腺肿、孕周、分娩方式、父亲的教育程度和吸烟状况以及近亲结婚。在大多数项目中，逻辑回归报告的关联比倾向得分分析更强，尽管差异无统计学意义。
我们探讨了众多潜在风险因素对先天性甲状腺炎的影响以及这些因素对疾病发生的影响。然而，需要未来的前瞻性研究来验证这些发现和假设，并调查这些潜在风险因素对先天性甲状腺炎的真实影响。
