自闭症谱系障碍患者在注视提示过程中前额叶伽马波段同步受损。

Impaired prefrontal gamma band synchrony in autism spectrum disorders during gaze cueing.

作者信息

Richard Annette E, Lajiness-O'Neill Renee R, Bowyer Susan M

机构信息

Department of Psychology, Mark Jefferson Science Complex, Eastern Michigan University, Ypsilanti, Michigan, USA.

出版信息

Neuroreport. 2013 Nov 13;24(16):894-7. doi: 10.1097/WNR.0000000000000015.

DOI:10.1097/WNR.0000000000000015

PMID:24077557

Abstract

Orienting to eye gaze is a vital social skill that is absent or developmentally delayed in autism spectrum disorders (ASD). Neural synchrony in the gamma frequency band is believed to be involved in perceptual and cognitive functions such as eye-gaze processing, and has been found to be abnormal in ASD. The current study used magnetoencephalography to measure neural synchrony in the gamma frequency band in neurotypicals (n=8) and individuals with ASD (n=10) while performing a directional eye-gaze processing task. Results support impaired generation of neural synchrony in the gamma frequency band during eye-gaze processing in ASD. Impaired gamma oscillatory activity in the prefrontal cortex may be associated with impairments in social cognitive functions such as eye-gaze processing in ASD.

摘要

定向于目光注视是一项至关重要的社交技能，在自闭症谱系障碍（ASD）中缺失或发育迟缓。人们认为，伽马频段的神经同步参与了诸如目光注视处理等感知和认知功能，并且已发现在ASD中存在异常。当前的研究使用脑磁图来测量神经典型个体（n = 8）和ASD个体（n = 10）在执行定向目光注视处理任务时伽马频段的神经同步。结果支持了ASD在目光注视处理过程中伽马频段神经同步的生成受损。前额叶皮层中伽马振荡活动受损可能与ASD中诸如目光注视处理等社会认知功能的损害有关。