γ波段异常作为自闭症谱系障碍的标志物。
γ-band abnormalities as markers of autism spectrum disorders.
作者信息
Rojas Donald C, Wilson Lisa B
机构信息
Department of Psychology, Campus Delivery 1876, Colorado State University, Fort Collins, CO 80523, USA.
出版信息
Biomark Med. 2014;8(3):353-68. doi: 10.2217/bmm.14.15.
Abstract
Autism is a behaviorally diagnosed neurodevelopmental disorder with no current biomarkers with high specificity and sensitivity. γ-band abnormalities have been reported in many studies of autism spectrum disorders. γ-band activity is associated with perceptual and cognitive functions that are compromised in autism. Some γ-band deficits have also been seen in unaffected first-degree relatives, suggesting heritability of these findings. This review covers the published literature on γ abnormalities in autism, the proposed mechanisms underlying the deficits and the potential for translation into new treatments. Although the utility of γ-band metrics as diagnostic biomarkers is currently limited, such changes in autism are also useful as endophenotypes, for evaluating potential neural mechanisms, and for use as surrogate markers of treatment response to interventions.
摘要
自闭症是一种通过行为诊断的神经发育障碍，目前尚无具有高特异性和敏感性的生物标志物。许多关于自闭症谱系障碍的研究都报道了γ波段异常。γ波段活动与自闭症中受损的感知和认知功能相关。在未受影响的一级亲属中也发现了一些γ波段缺陷，这表明这些发现具有遗传性。本综述涵盖了关于自闭症中γ异常的已发表文献、缺陷背后的潜在机制以及转化为新治疗方法的潜力。尽管γ波段指标作为诊断生物标志物的效用目前有限，但自闭症中的这种变化作为内表型、评估潜在神经机制以及作为干预治疗反应的替代标志物也很有用。
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