Lee Jong Joon, Kwon Oh Sang
Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University School of Medicine, Incheon, Korea.
Korean J Gastroenterol. 2013 Sep;62(3):160-4. doi: 10.4166/kjg.2013.62.3.160.
Many studies have suggested that occult HBV infection has a substantial clinical relevance to hepatocellular carcinoma (HCC). Occult HBV infection is an important risk factor for the development of cirrhosis and HCC in patients without HBsAg. As a matter of fact, occult HBV infection is one of the most common causes of crytogenic HCC in endemic areas of HBV. However, there still are controversial issues about the association between occult HBV infection and HCC according to the underlying liver disease. In alcoholic cirrhosis, occult HBV infection may exert synergistic effect on the development of HCC. However, there is insufficient evidence to relate occult HBV infection to hepatocarcinogenesis in non-alcoholic fatty liver disease. In cryptogenic HCC, occult HBV infection may play a direct role in the development of HCC. In order to elucidate the assocciation between occult HBV infection and HCC, underlying liver disease must be specified and larger number of cases must be included in future studies.
许多研究表明，隐匿性HBV感染与肝细胞癌（HCC）具有重要的临床相关性。隐匿性HBV感染是无HBsAg患者发生肝硬化和HCC的重要危险因素。事实上，隐匿性HBV感染是HBV流行地区隐源性HCC最常见的原因之一。然而，根据潜在的肝脏疾病，隐匿性HBV感染与HCC之间的关联仍存在争议。在酒精性肝硬化中，隐匿性HBV感染可能对HCC的发生起协同作用。然而，尚无足够证据表明隐匿性HBV感染与非酒精性脂肪性肝病的肝癌发生有关。在隐源性HCC中，隐匿性HBV感染可能在HCC的发生中起直接作用。为了阐明隐匿性HBV感染与HCC之间的关联，必须明确潜在的肝脏疾病，并且未来的研究必须纳入更多病例。
