羊角拗叶中的两个新色酮-生物碱类似物 Chrotacumines E 和 F。
Chrotacumines E and F, two new chromone-alkaloid analogs from Dysoxylum acutangulum (Meliaceae) leaves.
机构信息
Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia (phone: +603-89471490; fax: +603-89435380).
出版信息
Chem Biodivers. 2013 Sep;10(9):1589-96. doi: 10.1002/cbdv.201200391.
A chemical investigation of the alkaloidal fraction of Dysoxylum acutangulum leaves led to the isolation and characterization of two new chromone alkaloid analogs named chrotacumines E and F (1 and 2, resp.). Structure elucidation of 1 and 2 was achieved by spectroscopic analyses, including 2D-NMR. Both of these alkaloids exhibited modest activities as tyrosinase inhibitors with 29.2 and 25.8% inhibition at 100 μg/ml, respectively.
对 Dysoxylum acutangulum 叶的生物碱部分进行了化学研究，分离并鉴定了两种新的色酮生物碱类似物，命名为 chrotacumines E 和 F（1 和 2）。通过包括 2D-NMR 在内的光谱分析确定了 1 和 2 的结构。这两种生物碱均表现出适度的酪氨酸酶抑制活性，在 100μg/ml 时的抑制率分别为 29.2%和 25.8%。
Zotero 插件