羊毛硫抗生素类（T - 2636）抗生素的研究。十、羊毛硫抗生素类抗生素的微生物转化
Studies on lankacidin-group (T-2636) antibiotics. X. Microbial conversion of lankacidin-group antibiotics.
作者信息
Nakahama K, Harada S, Igarasi S
出版信息
J Antibiot (Tokyo). 1975 May;28(5):390-4. doi: 10.7164/antibiotics.28.390.
Lankacidin C, a component of lankacidin-group (T-2636) antibiotics, was esterified to lankacidin C 8-butyrate in the presence of methyl butyrate by culture broth and by cell-free extract of Bacillus megaterium IFO 12108. In addition, methyl isobutyrate, methyl valerate and methyl isovalerate served as acyl donors for the esterification, and lankacidin C 8-isobutyrate, lankacidin C 8-valerate and lankacidin C 8-isovalerate were formed respectively. Lankacidin C 8, 14-dibutyrate was hydrolyzed to lankacidin C 14-butyrate by the same organism.
兰卡杀菌素C是兰卡杀菌素族（T-2636）抗生素的一个组分，在丁酸甲酯存在的情况下，巨大芽孢杆菌IFO 12108的培养液和无细胞提取物可将其酯化为8-丁酸兰卡杀菌素C。此外，异丁酸甲酯、戊酸甲酯和异戊酸甲酯可用作酯化反应的酰基供体，分别生成8-异丁酸兰卡杀菌素C、8-戊酸兰卡杀菌素C和8-异戊酸兰卡杀菌素C。8,14-二丁酸兰卡杀菌素C可被同一菌株水解为14-丁酸兰卡杀菌素C。
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