Bajaj Vijay Kumar, Gupta Radhey S
Reproductive Physiology Section, Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur - 302004, India.
Nat Prod Commun. 2013 Aug;8(8):1183-93.
Male contraceptive development in the present scenario is most viable aspect of research due to uncontrolled population growth in the world. In this respect investigators are busy to find out a safe male contraceptive drug. Researchers have started their finding for a suitable drug from natural sources because these are safe and easily acceptable for common man, most of natural sources are plants and their products. In this review 137 plants and their effects on reproduction and reproductive physiology are summarized. Some of them have intense effect on male reproductive system and do not produce any side effects. Reproductive toxicological studies are also important aspects of these kinds of researches, so it is important that drugs are safe and widely acceptable. An ideal male contraceptive can influence semen, testes, hormone level, accessory reproductive organs and general physiology of animals and produced some alterations. Many plants in this review are showing antifertility as well as antispermatogenic effects, so these may be used for further study for contraceptives development but it is important to find out the mechanism of reaction and further laboratory and clinical research on some plants are needed for final male contraceptive drug development. In conclusion this review will help for finding suitable plant products for male contraceptive clinical and laboratory studies.
鉴于全球人口增长失控，当前男性避孕药物的研发是最具可行性的研究方向。在这方面，研究人员正忙于寻找一种安全的男性避孕药物。研究人员已开始从天然来源寻找合适的药物，因为这些药物安全且易于被大众接受，其中大部分天然来源是植物及其产品。本综述总结了137种植物及其对生殖和生殖生理学的影响。其中一些对男性生殖系统有显著影响且不产生任何副作用。生殖毒理学研究也是这类研究的重要方面，因此药物安全且广泛可接受很重要。理想的男性避孕药物可影响精液、睾丸、激素水平、附属生殖器官以及动物的一般生理机能，并产生一些改变。本综述中的许多植物显示出抗生育和抗生精作用，因此这些植物可用于避孕药研发的进一步研究，但找出反应机制很重要，并且为了最终开发男性避孕药物，还需要对一些植物进行进一步的实验室和临床研究。总之，本综述将有助于为男性避孕的临床和实验室研究找到合适的植物产品。
