• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

无环膦酸核苷衍生物的合成及生物学评价

Synthesis and biological evaluation of acyclic phosphonic acid nucleoside derivatives.

作者信息

Wainwright Philip, Maddaford Adrian, Zhang Xiurong, Billington Helen, Leese David, Glen Rebecca, Pryde David C, Middleton Donald S, Stephenson Peter T, Sutton Scott

机构信息

a Peakdale Molecular Ltd. , Chapel-en-le-Frith , Derbyshire , United Kingdom.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2013;32(9):477-92. doi: 10.1080/15257770.2013.820833.

DOI:10.1080/15257770.2013.820833
PMID:24079272
Abstract

As part of a project to generate a library of nucleosides as potential antiviral agents, a small subset of novel acyclic phosphonic acid nucleosides was prepared. Practical synthetic routes are described for three targets, which were then tested against HIV, hepatitis C virus (HCV), and Dengue virus.

摘要

作为生成潜在抗病毒剂核苷文库项目的一部分,制备了一小部分新型无环膦酸核苷。描述了针对三个目标化合物的实用合成路线,然后针对HIV、丙型肝炎病毒(HCV)和登革热病毒对它们进行了测试。

相似文献

1
Synthesis and biological evaluation of acyclic phosphonic acid nucleoside derivatives.无环膦酸核苷衍生物的合成及生物学评价
Nucleosides Nucleotides Nucleic Acids. 2013;32(9):477-92. doi: 10.1080/15257770.2013.820833.
2
Short synthesis and antiviral activity of acyclic phosphonic acid nucleoside analogues.无环膦酸核苷类似物的短链合成及抗病毒活性
Nucleosides Nucleotides Nucleic Acids. 2009 Feb;28(2):150-64. doi: 10.1080/15257770902736434.
3
Synthesis and antiviral evaluation of novel 2',2'-difluoro 5'-norcarbocyclic phosphonic acid nucleosides as antiviral agents.新型2',2'-二氟5'-去碳环膦酸核苷作为抗病毒剂的合成与抗病毒评价
Nucleosides Nucleotides Nucleic Acids. 2014;33(1):1-17. doi: 10.1080/15257770.2013.854380.
4
Synthesis and evaluation of novel 6',6'-difluoro 5'-deoxycarbocyclic phosphonic acid nucleosides as antiviral agents.新型6',6'-二氟5'-脱氧碳环膦酸核苷作为抗病毒药物的合成与评价
Nucleosides Nucleotides Nucleic Acids. 2013;32(7):396-410. doi: 10.1080/15257770.2013.797582.
5
Synthesis and Antiviral Activity Evaluation of 2',5',5'-Trifluoro-Apiosyl Nucleoside Phosphonic Acid Analogs.2',5',5'-三氟阿皮糖基核苷膦酸类似物的合成及抗病毒活性评价
Nucleosides Nucleotides Nucleic Acids. 2016;35(3):130-46. doi: 10.1080/15257770.2015.1115522. Epub 2016 Feb 8.
6
Synthesis and Anti-HIV Activity of Novel 2'-Deoxy-2'-β-Fluoro-Threosyl Nucleoside Phosphonic Acid Analogues.新型2'-脱氧-2'-β-氟苏糖核苷膦酸类似物的合成及抗HIV活性
Nucleosides Nucleotides Nucleic Acids. 2015;34(12):815-33. doi: 10.1080/15257770.2015.1076840. Epub 2015 Sep 25.
7
Efficient one-pot, three-component procedure to prepare new α-aminophosphonate and phosphonic acid acyclic nucleosides.高效一锅法、三组分法制备新型 α-氨基膦酸酯和无环核苷磷酸酯。
Nucleosides Nucleotides Nucleic Acids. 2021;40(1):43-67. doi: 10.1080/15257770.2020.1826516. Epub 2020 Oct 8.
8
Synthesis of novel 2'-fluoro-3'-hydroxymethyl-5'-deoxythreosyl phosphonic acid nucleoside analogues as antiviral agents.新型2'-氟-3'-羟甲基-5'-脱氧苏糖基膦酸核苷类似物作为抗病毒药物的合成
Nucleosides Nucleotides Nucleic Acids. 2014;33(2):92-109. doi: 10.1080/15257770.2013.874561.
9
Efficient electrophilic fluorination for the synthesis of novel 2'-fluoro-3'-methyl-5'-deoxyphosphonic acid apiosyl nucleoside analogues.用于合成新型2'-氟-3'-甲基-5'-脱氧膦酸阿朴糖基核苷类似物的高效亲电氟化反应。
Nucleosides Nucleotides Nucleic Acids. 2013;32(10):555-70. doi: 10.1080/15257770.2013.832774.
10
Synthesis and anti-HCMV activity of novel cyclopropyl phosphonic acid nucleosides.新型环丙基膦酸核苷的合成及其抗人巨细胞病毒活性
Nucleosides Nucleotides Nucleic Acids. 2006;25(12):1399-406. doi: 10.1080/15257770600918920.