Wainwright Philip, Maddaford Adrian, Zhang Xiurong, Billington Helen, Leese David, Glen Rebecca, Pryde David C, Middleton Donald S, Stephenson Peter T, Sutton Scott
a Peakdale Molecular Ltd. , Chapel-en-le-Frith , Derbyshire , United Kingdom.
Nucleosides Nucleotides Nucleic Acids. 2013;32(9):477-92. doi: 10.1080/15257770.2013.820833.
As part of a project to generate a library of nucleosides as potential antiviral agents, a small subset of novel acyclic phosphonic acid nucleosides was prepared. Practical synthetic routes are described for three targets, which were then tested against HIV, hepatitis C virus (HCV), and Dengue virus.
作为生成潜在抗病毒剂核苷文库项目的一部分,制备了一小部分新型无环膦酸核苷。描述了针对三个目标化合物的实用合成路线,然后针对HIV、丙型肝炎病毒(HCV)和登革热病毒对它们进行了测试。