Department of Microbiology, Jahangirnagar University, Savar, Dhaka, Bangladesh.
Infect Genet Evol. 2013 Dec;20:325-9. doi: 10.1016/j.meegid.2013.09.021. Epub 2013 Sep 27.
Noroviruses (NoVs) are one of the major etiological agents of acute gastroenteritis in all age groups. In this study, we identified an intergenotype NoV recombinant strain in the fecal specimens of two male infants with acute diarrhea in Bangladesh. Phylogenetic analysis showed that the identified strains were recombinant NoV strains with a GII.3 capsid and a GII.16 polymerase gene. The recombination breakpoint was located in the ORF1/ORF2 overlap region. To the best of our knowledge this is the first report of a NoV recombinant GII.16/GII.3 strain worldwide.
诺如病毒（NoV）是所有年龄段人群急性胃肠炎的主要病因之一。在本研究中，我们在孟加拉国两名急性腹泻男婴的粪便标本中鉴定出一种属间 NoV 重组株。系统进化分析显示，鉴定出的毒株为 GII.3 衣壳和 GII.16 聚合酶基因的 GII.16/GII.3 型 NoV 重组株。重组断点位于 ORF1/ORF2 重叠区。据我们所知，这是全球首次报道的 NoV 重组 GII.16/GII.3 株。
