组织转谷氨酰胺酶是阿尔茨海默病的一种生化标志物。 - Suppr

Tissue transglutaminase is a biochemical marker for Alzheimer's disease.

作者信息

Wilhelmus Micha M M, Drukarch Benjamin

机构信息

Department of Anatomy and Neurosciences, Cellular Neuropharmacology Section, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.

出版信息

Neurobiol Aging. 2014 Apr;35(4):e3-4. doi: 10.1016/j.neurobiolaging.2013.08.022. Epub 2013 Sep 27.

DOI:10.1016/j.neurobiolaging.2013.08.022

PMID:24080177

Abstract

摘要

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Tissue transglutaminase is a biochemical marker for Alzheimer's disease.组织转谷氨酰胺酶是阿尔茨海默病的一种生化标志物。

Neurobiol Aging. 2014 Apr;35(4):e3-4. doi: 10.1016/j.neurobiolaging.2013.08.022. Epub 2013 Sep 27.

Tissue transglutaminase in Alzheimer's disease - facts and fiction: a reply to "Tissue transglutaminase is a biochemical marker for Alzheimer's disease".

Neurobiol Aging. 2014 Apr;35(4):e5-9. doi: 10.1016/j.neurobiolaging.2013.09.042. Epub 2013 Nov 7.

Tissue transglutaminase is not a biochemical marker for Alzheimer's disease.组织转谷氨酰胺酶不是阿尔茨海默病的生化标志物。

Neurobiol Aging. 2013 Nov;34(11):2495-8. doi: 10.1016/j.neurobiolaging.2013.05.008. Epub 2013 Jun 5.

Cerebrospinal fluid tissue transglutaminase in vascular dementia.血管性痴呆中的脑脊液组织转谷氨酰胺酶

J Neurol Sci. 2002 Nov 15;203-204:207-9. doi: 10.1016/s0022-510x(02)00292-7.

Tissue transglutaminase-catalysed cross-linking induces Apolipoprotein E multimers inhibiting Apolipoprotein E's protective effects towards amyloid-beta-induced toxicity.组织转谷氨酰胺酶催化的交联反应诱导载脂蛋白E多聚体，抑制载脂蛋白E对β淀粉样蛋白诱导毒性的保护作用。

J Neurochem. 2015 Sep;134(6):1116-28. doi: 10.1111/jnc.13203. Epub 2015 Jul 7.

Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis.帕金森病患者脑脊液组织转谷氨酰胺酶浓度升高提示细胞凋亡。

Mov Disord. 2004 Oct;19(10):1252-4. doi: 10.1002/mds.20197.

Tissue transglutaminase in Alzheimer's disease: involvement in pathogenesis and its potential as a therapeutic target.阿尔茨海默病中的组织转谷氨酰胺酶：参与发病机制及其作为治疗靶点的潜力。

J Alzheimers Dis. 2014;42 Suppl 3:S289-303. doi: 10.3233/JAD-132492.

Identification of brain substrates of transglutaminase by functional proteomics supports its role in neurodegenerative diseases.通过功能蛋白质组学鉴定转谷氨酰胺酶的脑内底物，支持其在神经退行性疾病中的作用。

Neurobiol Dis. 2017 May;101:40-58. doi: 10.1016/j.nbd.2017.01.007. Epub 2017 Jan 27.

Tissue transglutaminase colocalizes with extracellular matrix proteins in cerebral amyloid angiopathy.组织转谷氨酰胺酶在脑淀粉样血管病中外周基质蛋白中共同定位。

Neurobiol Aging. 2013 Apr;34(4):1159-69. doi: 10.1016/j.neurobiolaging.2012.10.005. Epub 2012 Oct 31.

Biomarkers for apoptosis in Alzheimer's disease.

Int J Geriatr Psychiatry. 2005 Feb;20(2):101-5. doi: 10.1002/gps.1260.

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Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models.转谷氨酰胺酶 6 在亨廷顿病啮齿动物模型中与突变型亨廷顿蛋白共定位并相互作用。

Int J Mol Sci. 2021 Aug 18;22(16):8914. doi: 10.3390/ijms22168914.

The gliadin peptide 31-43 exacerbates kainate neurotoxicity in epilepsy models.麦醇溶蛋白肽 31-43 可加重癫痫模型中的红藻氨酸神经毒性。

Sci Rep. 2017 Nov 9;7(1):15146. doi: 10.1038/s41598-017-14845-4.

Catalytically active tissue transglutaminase colocalises with Aβ pathology in Alzheimer's disease mouse models.在阿尔茨海默病小鼠模型中，具有催化活性的组织转谷氨酰胺酶与β淀粉样蛋白病变共定位。

Sci Rep. 2016 Feb 3;6:20569. doi: 10.1038/srep20569.

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Tissue transglutaminase is a biochemical marker for Alzheimer's disease.

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