Integrating advances in insulin into clinical practice: Advances In insulin formulations.

The central role of insulin in the management of patients with type 1 diabetes mellitus (T1DM) remains, nearly a century after its first use in humans. In patients with type 2 diabetes mellitus (T2DM), the role of insulin has evolved as other therapies have been introduced, with insulin now used across the spectrum of the disease. This article discusses the use of insulin in patients with T1DM or T2DM, including combined use with other agents in T2DM, with an emphasis on incretin-based therapies. In addition, new insulin products and concentrations are discussed along with their varied routes of administration.