George Institute for Global Health, Splendor Forum, Jasola, New Delhi, India.
Nat Rev Nephrol. 2013 Nov;9(11):635-6. doi: 10.1038/nrneph.2013.205. Epub 2013 Oct 1.
Two trials of low-glucose-containing peritoneal dialysis regimen in patients with diabetes mellitus show that although this strategy improved glycaemic control, it was associated with increased risk of serious adverse events and mortality. These studies suggest caution is needed when evaluating effectiveness using surrogate measures and awareness of confounding factors is important.
两项针对糖尿病患者的低葡萄糖含量腹膜透析方案的试验表明,尽管这种策略改善了血糖控制,但与严重不良事件和死亡率增加有关。这些研究表明,在使用替代指标评估疗效时需要谨慎,并且认识混杂因素很重要。