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药理受体:分类、命名和结构纲要的必要性。

Pharmacological receptors: the need for a compendium of classification, nomenclature and structure.

作者信息

Green J P

机构信息

Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, NY 10029.

出版信息

Trends Pharmacol Sci. 1990 Jan;11(1):13-6. doi: 10.1016/0165-6147(90)90035-7.

Abstract

In an attempt to contain the chaos of receptor nomenclature, the supplement distributed with this issue of TiPS catalogues cell surface receptors and their subtypes according to the most commonly used nomenclature and describes them in pharmacological, biochemical and molecular terms. This reporting of the status quo will be an invaluable aid to communication, but all scientists (not just pharmacologists) working on receptors would agree that a radical and rational classification of receptors also needs to be initiated. In this article, Jack Peter Green proposes a system of (and mechanism for) classification that should satisfy both the 'taxonomic realists' and the 'taxonomic skeptics'.

摘要

为了遏制受体命名的混乱局面,本期《药物科学趋势》(TiPS)增刊根据最常用的命名法对细胞表面受体及其亚型进行了编目,并从药理学、生物化学和分子层面进行了描述。这种对现状的报告将对交流大有帮助,但所有从事受体研究的科学家(不仅仅是药理学家)都会认同,还需要启动一种彻底且合理的受体分类方法。在本文中,杰克·彼得·格林提出了一种分类体系(及机制),有望同时满足“分类实在论者”和“分类怀疑论者”的需求。

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