Soochow University, College of Pharmaceutical Science , Suzhou 215123 , PR China.
Expert Opin Ther Pat. 2014 Jan;24(1):19-27. doi: 10.1517/13543776.2014.847091. Epub 2013 Oct 1.
Fatty acid biosynthesis is essential for the bacterial viability and growth. In recent years, β-ketoacyl-acyl carrier protein synthase III (FabH) become an attractive new target, which catalyzes the first step of fatty acid biosynthesis, and FabH inhibitors could be potential candidates for antibacterial agents. In this review, recent advances in the research of FabH inhibitors are reviewed.
This updated review summarized new patents and articles publications on FabH inhibitors within July 2012 to June 2013.
The review gives the latest development in the area of FabH inhibitors which aim to solve the bacterial resistance. The potent antibacterial activities of the selected compounds are probably correlated to their FabH inhibitory. Molecular docking of the most potent compound in every kind of compounds against FabH was also reviewed to explore the binding mode of the compound at the active site.
脂肪酸生物合成对于细菌的存活和生长至关重要。近年来，β-酮酰-酰基载体蛋白合酶 III（FabH）成为一个有吸引力的新靶点，它催化脂肪酸生物合成的第一步，FabH 抑制剂可能是有潜力的抗菌剂候选物。本文综述了 FabH 抑制剂的研究进展。
本文综述了 2012 年 7 月至 2013 年 6 月期间 FabH 抑制剂的新专利和文章出版物。
综述介绍了 FabH 抑制剂领域的最新进展，旨在解决细菌耐药性问题。所选化合物具有很强的抗菌活性，这可能与其 FabH 抑制作用有关。还对每种类型化合物中最有效的化合物与 FabH 的分子对接进行了综述，以探讨化合物在活性部位的结合模式。
