Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu Province, People's Republic of China.
World J Surg Oncol. 2013 Oct 1;11:246. doi: 10.1186/1477-7819-11-246.
α-Fetoprotein-producing gastric cancer (AFPGC) is a rare type of gastric cancer. The largest population of patients with AFPGC is found in China. In the present study, a total of 4,779 GC patients, including 317 AFPGC patients, from 11 clinical studies in China with a general AFPGC/GC ratio of 6.63% were summarized and analyzed. On the basis of analysis of the clinical data, the patients with AFPGC had larger tumor size, weaker cell differentiation, worse histopathological types, deeper serosal infiltration, more lymph node and liver metastases, poorer stages, shorter survival time and more positive expression of vascular endothelial growth factors than the patients without AFPGC. Our observation is consistent with previous results reported in studies of AFPGC. Overall, AFPGC is a subtype of GC with a poor prognosis.
甲胎蛋白阳性胃癌（AFPGC）是一种罕见的胃癌类型。AFPGC 患者数量最多的是中国。本研究共总结分析了来自中国的 11 项临床研究的 4779 例 GC 患者，其中 317 例为 AFPGC 患者，AFPGC/GC 比例一般为 6.63%。基于临床数据分析，AFPGC 患者的肿瘤体积较大，细胞分化较弱，组织病理学类型较差，浆膜浸润较深，淋巴结和肝转移较多，分期较差，生存时间较短，血管内皮生长因子表达阳性率较高。我们的观察结果与之前报道的 AFPGC 研究结果一致。总体而言，AFPGC 是一种预后不良的 GC 亚型。
