School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
Curr Top Med Chem. 2013;13(21):2684-733. doi: 10.2174/15680266113136660195.
The last two decades are characterized by major increases in the incidence of systemic fungal infections caused by the yeast Candida albicans, particularly in immunocompromised patients. On the other hand it was observed the increased number of pathogenic microorganisms with multiple resistance to drugs. Also there is a big variety of drugs for the treatment of candidiasis, only two drugs are used for the treatment of infections from Aspergillus fumigatus. Taking into account that the long term therapy with azoles results in resistance a critical need exists for new antifungal agents with fewer side effecgts to treat these life-threatening fungal infections. This review will cover the advances in research of biological activity of different compounds from different chemical classes with focus on their antifungal properties.
过去二十年的特点是免疫功能低下患者中由白色念珠菌引起的系统性真菌感染发病率显著增加。另一方面，人们观察到具有多种药物耐药性的致病微生物数量增加。此外，虽然有多种药物可用于治疗念珠菌病，但只有两种药物可用于治疗烟曲霉感染。鉴于唑类药物的长期治疗会导致耐药性，因此迫切需要具有较少副作用的新型抗真菌药物来治疗这些危及生命的真菌感染。本综述将涵盖不同化学类别中不同化合物的生物活性研究进展，重点关注其抗真菌特性。
