Department of Chemistry, Technische Universität Dresden, Bergstr. 66, 01069 Dresden, Germany.
Bioorg Med Chem Lett. 2013 Nov 15;23(22):6111-3. doi: 10.1016/j.bmcl.2013.09.013. Epub 2013 Sep 14.
A variety of cholestan-3β-ol derivatives, which are oxygenated at different positions of the steroid ring system, were prepared and tested for their inhibition of the Mycobacterium tuberculosis H37Rv strain. Several compounds showed significant antitubercular activities with MIC90 values in the range 4-8 μM and low or non-detectable toxicity against mammalian cells.
制备了多种甾体环系统不同位置含氧的胆甾-3β-醇衍生物，并对其抑制结核分枝杆菌 H37Rv 株的活性进行了测试。几种化合物表现出显著的抗结核活性，MIC90 值在 4-8 μM 范围内，对哺乳动物细胞的毒性低或无法检测。
