UMR 7247, INRA-CNRS-Université de Tours-Haras Nationaux, 37380 Nouzilly, France.
UMR 7247, INRA-CNRS-Université de Tours-Haras Nationaux, 37380 Nouzilly, France.
Mol Cell Endocrinol. 2014 Jan 25;382(1):527-537. doi: 10.1016/j.mce.2013.09.028. Epub 2013 Sep 29.
There is extensive evidence that nutrition influences reproductive function in various mammalian species (agricultural animals, rodents and human). However, the mechanisms underlying the relationship between nutrition, energy metabolism and reproductive function are poorly understood. This review considers nutrient sensors as a molecular link between food molecules and consequences for female and male fertility. It focuses on the roles and the molecular mechanisms of some of the relevant hormones, such as insulin and adipokines, and of energy substrates (glucose, fatty acids and amino acids), in the gonadotropic axis (central nervous system and gonads). A greater understanding of the interactions between nutrition and fertility is required for both better management of the physiological processes and the development of new molecules to prevent or cure metabolic diseases and their consequences for fertility.
有大量证据表明，营养会影响各种哺乳动物物种（农业动物、啮齿动物和人类）的生殖功能。然而，营养、能量代谢和生殖功能之间的关系的机制尚不清楚。这篇综述考虑了营养传感器作为食物分子与女性和男性生育能力之间关系的分子联系。它重点介绍了一些相关激素（如胰岛素和脂肪因子）以及能量底物（葡萄糖、脂肪酸和氨基酸）在促性腺轴（中枢神经系统和性腺）中的作用和分子机制。为了更好地管理生理过程并开发新的分子来预防或治疗代谢疾病及其对生育能力的影响，需要更好地了解营养与生育能力之间的相互作用。
