利用红细胞将化疗药物输送至网状内皮系统。

The use of erythrocytes for delivery of chemotherapeutic agents to the reticuloendothelial system.

作者信息

Lynch W E, Sartiano G P, Rosenblum S L, Calkins J H, Ramsey C B

出版信息

Bibl Haematol. 1985(51):42-9. doi: 10.1159/000410226.

Abstract

The object of our work is to define the possible role of hypotonically loaded erythrocytes as carriers to target drugs to the reticuloendothelial system. We have examined choices of drugs for loading into the erythrocytes and have considered methods of altering potentially useful agents so that they will load. We have demonstrated that the delivery of bleomycin to the reticuloendothelial system of mice, inside erythrocyte carriers, potentiates the effect of this drug on phagocytosis. We speculate, that this targeted delivery of bleomycin to phagocytes could be beneficial in the treatment of diseases characterized by an important phagocytic component.

摘要

我们工作的目的是确定低渗加载的红细胞作为载体将药物靶向网状内皮系统的潜在作用。我们研究了用于加载到红细胞中的药物选择，并考虑了改变潜在有用药物以便它们能够加载的方法。我们已经证明，在红细胞载体内部，博来霉素向小鼠网状内皮系统的递送增强了该药物对吞噬作用的效果。我们推测，这种将博来霉素靶向递送至吞噬细胞可能对治疗以重要吞噬成分为特征的疾病有益。