INSERM UMR1098, F25020 Besançon cedex, France.
Immunotherapy. 2013 Oct;5(10):1055-73. doi: 10.2217/imt.13.103.
Apoptotic cell removal or interactions of early-stage apoptotic cells with immune cells are associated with an immunomodulatory microenvironment that can be harnessed to exert therapeutic effects. While the involved immune mechanisms are still being deciphered, apoptotic cell infusion has been tested in different experimental models where inflammation is deregulated. This includes chronic and acute inflammatory disorders such as arthritis, contact hypersensitivity and acute myocardial infarction. Apoptotic cell infusion has also been used in transplantation settings to prevent or treat acute and chronic rejection, as well as to limit acute graft-versus-host disease associated with allogeneic hematopoietic cell transplantation. Here, we review the mechanisms involved in apoptotic cell-induced immunomodulation and data obtained in preclinical models of transplantation and inflammatory diseases.
凋亡细胞的清除或早期凋亡细胞与免疫细胞的相互作用与免疫调节微环境相关，可被利用来发挥治疗效果。虽然涉及的免疫机制仍在破译中，但凋亡细胞输注已在不同的炎症失调的实验模型中进行了测试。这包括关节炎、接触性超敏反应和急性心肌梗死等慢性和急性炎症性疾病。凋亡细胞输注也已用于移植环境中，以预防或治疗急性和慢性排斥反应，并限制与异基因造血细胞移植相关的急性移植物抗宿主病。在这里，我们综述了凋亡细胞诱导免疫调节的相关机制以及在移植和炎症性疾病的临床前模型中获得的数据。
