Division of Medical Oncology & Hematology, Department of Medicine, Princess Margaret Hospital/University of Toronto, Toronto, ON, Canada.
Pharmacogenomics. 2013 Oct;14(13):1659-67. doi: 10.2217/pgs.13.165.
With the recent advances in genomic medicine and the development of targeted antiangiogenic therapy for cancer patients, there has been an increased interest in the role of predictive and prognostic markers for antiangiogenic therapy. Here, we provide a summary of the angiogenesis pathway, the role of predictive and prognostic markers in cancer and a summary of the current literature and studies on predictive and prognostic markers for antiangiogenic therapy. Our aim is to summarize those studies that are currently in the literature with an emphasis on the future directions of the field from 2013 and beyond. We conclude by providing our perspective on the future directions of this growing field, as well as possible challenges and pitfalls along the way.
随着基因组医学的最新进展和针对癌症患者的靶向抗血管生成治疗的发展，人们对预测和预后标志物在抗血管生成治疗中的作用产生了浓厚的兴趣。在这里，我们总结了血管生成途径、预测和预后标志物在癌症中的作用以及抗血管生成治疗的预测和预后标志物的当前文献和研究概述。我们的目的是总结目前文献中的这些研究，并重点介绍 2013 年及以后该领域的未来发展方向。最后，我们对这个不断发展的领域的未来方向以及可能遇到的挑战和陷阱提出了我们的看法。
