Kurek Krzysztof, Piotrowska Dominika M, Wiesiołek-Kurek Patrycja, Chabowska Anna, Łukaszuk Bartłomiej, Żendzian-Piotrowska Małgorzata
Zakład Fizjologii Uniwersytetu Medycznego w Białymstoku.
Postepy Hig Med Dosw (Online). 2013 Sep 30;67:1018-26. doi: 10.5604/17322693.1068694.
Bioactive sphingolipids are engaged with numerous cellular processes such as cell differentiation, proliferation and apoptosis. Sphingolipid metabolism in heart is regulated by physical exercise and PPARs. Ceramide, the main second messenger of sphingomyelin pathway of signal transduction, was found to be involved in development of cardiac dysfunction after ischemia/reperfusion. On the other hand ceramide derivative sphingosine- 1- phosphate has been shown to exert potent cardioprotective action and guards cardiomyocytes against ischemic/reperfusion injury. Pharmacological compounds, which regulate metabolism of sphingolipids can be potentially useful in treatment of selected cardiovascular diseases. The aim of this work is critical review of physiological and pathological role of sphingolipids in circulatory system.
生物活性鞘脂参与众多细胞过程，如细胞分化、增殖和凋亡。心脏中的鞘脂代谢受体育锻炼和过氧化物酶体增殖物激活受体（PPARs）调节。神经酰胺是信号转导鞘磷脂途径的主要第二信使，已发现其参与缺血/再灌注后心脏功能障碍的发展。另一方面，神经酰胺衍生物鞘氨醇-1-磷酸已被证明具有强大的心脏保护作用，并能保护心肌细胞免受缺血/再灌注损伤。调节鞘脂代谢的药理化合物可能对治疗某些心血管疾病有用。这项工作的目的是对鞘脂在循环系统中的生理和病理作用进行批判性综述。
