Fukunaga Akiko, Iwamoto Yoshihiro, Inano Shojiro, Sueki Yuki, Yoshinaga Noriyoshi, Yanagida Soshi, Arima Nobuyoshi
Kitano Hospital, Japan.
Intern Med. 2013;52(19):2265-9. doi: 10.2169/internalmedicine.52.0537. Epub 2012 Mar 1.
Immune reconstitution inflammatory syndrome (IRIS) is associated with clinical manifestations that can overlap with the patients with acquired immunodeficiency disease (AIDS)-related non-Hodgkin's lymphoma. We herein report a case of AIDS-related Burkitt lymphoma which was successfully treated with dose-adjusted etoposide, doxorubicin, cyclophosphamide, vincristine, and prednisone (EPOCH). However, the patient developed a lymphoma-like clinical presentation shortly after the conclusion of chemotherapy. The patient's symptoms were identical to the initial symptoms characteristic of lymphoma; however, the laboratory data revealed no evidence of a relapse of Burkitt lymphoma. A bone marrow examination showed T-cell clonality, even though there were no signs of any progression of the lymphoma. The patient was diagnosed with IRIS, and the clinical manifestations rapidly improved following treatment.
免疫重建炎症综合征（IRIS）的临床表现可能与获得性免疫缺陷病（AIDS）相关的非霍奇金淋巴瘤患者的临床表现重叠。我们在此报告一例AIDS相关的伯基特淋巴瘤患者，该患者成功接受了剂量调整的依托泊苷、阿霉素、环磷酰胺、长春新碱和泼尼松（EPOCH）治疗。然而，患者在化疗结束后不久出现了淋巴瘤样的临床表现。患者的症状与淋巴瘤最初的特征性症状相同；然而，实验室数据未显示伯基特淋巴瘤复发的证据。骨髓检查显示T细胞克隆性，尽管没有淋巴瘤进展的迹象。该患者被诊断为IRIS，治疗后临床表现迅速改善。
