Lehle G, Weiler E
Eur J Immunol. 1985 Jun;15(6):580-6. doi: 10.1002/eji.1830150610.
BALB/c and BALB/c nu/nu mice were shown to express to a variable extent in their response against dextran B1355S (Dex), an idiotype which is present on the Dex-reactive BALB/c myeloma protein MOPC 104E. Injection of minute amounts of syngeneic anti-MOPC 104E idiotype antisera into neonatal euthymic or athymic BALB/c mice suppressed this idiotype in the Dex-specific response of the adult animals. When spleen cells from suppressed BALB/c mice were transferred into irradiated BALB Ighb mice the state of suppression persisted. Data are discussed with respect to possible mechanisms regulating expression of this idiotype.
研究表明，BALB/c和BALB/c nu/nu小鼠在针对葡聚糖B1355S（Dex）的反应中表达程度各异，Dex是存在于与Dex反应的BALB/c骨髓瘤蛋白MOPC 104E上的一种独特型。向新生的正常胸腺或无胸腺BALB/c小鼠注射微量同基因抗MOPC 104E独特型抗血清，可抑制成年动物对Dex的特异性反应中的这种独特型。当将受抑制的BALB/c小鼠的脾细胞转移到经照射的BALB Ighb小鼠中时，抑制状态持续存在。文中就调节这种独特型表达的可能机制进行了讨论。
