Zheutlin L M, Ackerman S J, Gleich G J, Thomas L L
Int Arch Allergy Appl Immunol. 1985;77(1-2):216-7. doi: 10.1159/000233791.
Leukocytes of 22 individuals were incubated with a suboptimal concentration of eosinophil granule major basic protein and the amount of histamine release was determined. Cells from 20 of the 22 donors had a histamine release of greater than or equal to 15%. The use of selected donors on repeated occasions revealed significant variability in individual donor responsiveness. The findings support a role for major basic protein activation of human basophils in allergic reactions.
将22名个体的白细胞与嗜酸性粒细胞颗粒主要碱性蛋白的亚最佳浓度一起孵育，并测定组胺释放量。22名供体中有20名的细胞组胺释放量大于或等于15%。在重复的情况下使用选定的供体显示个体供体反应性存在显著差异。这些发现支持主要碱性蛋白激活人嗜碱性粒细胞在过敏反应中的作用。
