Molenaar W M, Ellens H, van den Berg H M
Invasion Metastasis. 1985;5(4):206-17.
A high-grade malignant lymphoma that arose spontaneously in a C57BL mouse has been transplanted by intraperitoneal injection of a single cell suspension for over 20 years. In the current study it was characterized cytohistologically and immunologically and was found to be a high-grade malignant (immunoblastic) B-lymphoma. The distribution in the various organs and the peripheral blood was investigated after intraperitoneal and intravenous injection and the effect of splenectomy was studied. The findings suggest that the major initial proliferation of lymphoma cells occurs in the spleen both after intraperitoneal and intravenous injection. The second, final stage is characterized by leukemic infiltration throughout the body organs. The current observations are compared to those concerning the previously described, low-grade malignant murine BCL1-lymphoma.
一只C57BL小鼠自发产生的高级别恶性淋巴瘤，通过腹腔注射单细胞悬液已移植了20多年。在当前研究中，对其进行了细胞组织学和免疫学特征分析，发现它是一种高级别恶性（免疫母细胞性）B细胞淋巴瘤。在腹腔注射和静脉注射后，研究了淋巴瘤细胞在各个器官和外周血中的分布，并研究了脾切除的效果。研究结果表明，无论是腹腔注射还是静脉注射后，淋巴瘤细胞的主要初始增殖都发生在脾脏。第二个也是最后阶段的特征是白血病细胞浸润全身各器官。将当前的观察结果与先前描述的低级别恶性小鼠BCL1淋巴瘤的观察结果进行了比较。
