Carlino Cristiana, Zaratti Laura, Franco Elisabetta
Scuola di Specializzazione in Igiene e Medicina Preventiva, Università di Roma Tor Vergata.
Ig Sanita Pubbl. 2013 Jul-Aug;69(4):473-80.
Pertussis is still a major Public Health problem. In fact, despite high vaccination coverage, several outbreaks have occurred in the last years all over the world, with thousands of cases and several deaths. Waning immunity seems to be the origin of this phenomenon, causing the shift of the peak incidence of the disease from school-age children, typical of the pre-vaccination era, to adolescents and adults. From these subjects the infection spreads to infants who have not yet been vaccinated or who have not completed the vaccination cycle. To reduce the incidence and the complications of pertussis in infants and immune compromised persons, booster doses are recommended and a "cocoon" vaccination strategy has been proposed.
百日咳仍然是一个主要的公共卫生问题。事实上，尽管疫苗接种覆盖率很高，但在过去几年里世界各地仍发生了几起疫情，出现了数千例病例并有数人死亡。免疫力下降似乎是这一现象的根源，导致疾病的发病高峰从疫苗接种前时代典型的学龄儿童，转移到青少年和成年人。感染从这些人群传播到尚未接种疫苗或未完成疫苗接种周期的婴儿。为降低婴儿和免疫功能低下者百日咳的发病率及并发症，建议接种加强剂量疫苗，并提出了“茧式”疫苗接种策略。
