Rothmann S A, Paul P, Oluic' T J, Sturkie K A, Proffitt M R
J Interferon Res. 1985 Spring;5(2):273-8. doi: 10.1089/jir.1985.5.273.
In an attempt to induce circulating interferon (IFN) chronically, C57BL/6 or Balb/cBy mice received daily injections or continuous infusion of polyriboinosinic:polyribocytidilic acid [poly(I:C)] i.p. for 7 days. Significantly higher plasma IFN was present in C57BL/6 mice receiving poly(I:C) via continuous infusion compared with daily injections. Spleen and bone marrow natural killer (NK) cells were elevated only in the group receiving poly(I:C) continuously. Little IFN was induced acutely in Balb/cBy mice and none was present after chronic infusion of poly(I:C). NK cells were not elevated. Continuous infusion of poly(I:C) appears to overcome the hyporesponsiveness to repeated IFN induction in a susceptible mouse strain.
为了长期诱导循环干扰素（IFN），C57BL/6或Balb/cBy小鼠腹腔内每日注射或持续输注聚肌苷酸:聚胞苷酸[poly（I:C）]，持续7天。与每日注射相比，通过持续输注接受聚（I:C）的C57BL/6小鼠血浆IFN显著更高。仅在持续接受聚（I:C）的组中，脾脏和骨髓自然杀伤（NK）细胞有所升高。Balb/cBy小鼠急性诱导产生的IFN很少，慢性输注聚（I:C）后则没有IFN。NK细胞没有升高。持续输注聚（I:C）似乎克服了易感小鼠品系对重复IFN诱导的低反应性。
