Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Chin J Integr Med. 2013 Oct;19(10):783-91. doi: 10.1007/s11655-013-1591-7. Epub 2013 Oct 4.
To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills (, LDP) to Western medicine in improving treatment outcomes for type 2 diabetes.
Medline, PubMed, Cochrane Library, and Chinese databases, including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e., if the study involved a randomized clinical trial in which the experimental group combined LDP with Western drugs and the control group used the corresponding Western drugs alone to treat type 2 diabetes. Outcomes were measured in terms of fasting blood glucose (FBG), postprandial blood glucose (2hPG) and HbA1c level. Efficacy was also measured by using control and response rates. The combined odds ratio (OR), mean difference (MD), and 95% confidence intervals (95% CI) were calculated.
Studies included in the analysis were less adequate than expected in terms of methodological quality. A total of 1,609 patients from 18 studies were included. We found that adding LDP can lower patients' FBG (MD=0.54 mmol/L, 95% CI [0.15, 0.93], P=0.007), 2hPG (MD=1.05 mmol/L, 95% CI [0.29, 1.81], P<0.01) and HbA1c (MD=0.23, 95% CI [0.02, 0.45], P=0.008). There were also improvements in treatment response rates (OR=3.41, 95% CI [2.38, 4.90], P<0.01) and control rates (OR=2.47, 95% CI [1.91, 3.20], P<0.01).
Adding LDP to Western medicine might improve treatment outcomes of diabetes, including FBG, 2hPG, response rates and control rates.
进行荟萃分析评估加味六味地黄丸（LDP）对改善 2 型糖尿病治疗效果的疗效。
检索 Medline、PubMed、Cochrane 图书馆和中国数据库，包括中国国家知识基础设施，以确定合格的研究；即，如果研究涉及一项随机临床试验，其中实验组将 LDP 与西药联合使用，对照组单独使用相应的西药治疗 2 型糖尿病。结果以空腹血糖（FBG）、餐后血糖（2hPG）和 HbA1c 水平来衡量。疗效也通过控制和反应率来衡量。计算合并的比值比（OR）、平均差异（MD）和 95%置信区间（95%CI）。
分析中纳入的研究在方法学质量方面不如预期的充分。共有 18 项研究的 1609 名患者纳入研究。我们发现，加味六味地黄丸可降低患者的 FBG（MD=0.54mmol/L，95%CI[0.15，0.93]，P=0.007）、2hPG（MD=1.05mmol/L，95%CI[0.29，1.81]，P<0.01）和 HbA1c（MD=0.23，95%CI[0.02，0.45]，P=0.008）。治疗反应率（OR=3.41，95%CI[2.38，4.90]，P<0.01）和控制率（OR=2.47，95%CI[1.91，3.20]，P<0.01）也有所提高。
加味六味地黄丸联合西药可能改善糖尿病的治疗效果，包括 FBG、2hPG、反应率和控制率。
