Sassi Yassine, Hulot Jean-Sébastien
INSERM/Université Pierre et Marie Curie UMRS 956, Paris, France.
Handb Exp Pharmacol. 2013;218:513-29. doi: 10.1007/978-3-642-38664-0_20.
Cyclic nucleotides (e.g., cAMP and cGMP) are ubiquitous second messengers that affect multiple cell functions including vascular tone and vascular cell proliferation. After production, different processes can regulate the concentration of cyclic nucleotides. Cyclic nucleotides' degradation by phosphodiesterase (PDE) enzymes has well-known roles in regulating cyclic nucleotides concentrations. Recently, recognition of ATP-binding cassette (ABC) transporter contribution to both local and global regulation of cAMP has been acknowledged. Recent data support an important role of cyclic nucleotide efflux in the pathobiology of pulmonary hypertension, thus suggesting that inhibition of cyclic nucleotide efflux proteins might be a useful strategy to prevent and treat PH.
环核苷酸（如cAMP和cGMP）是普遍存在的第二信使，可影响多种细胞功能，包括血管张力和血管细胞增殖。产生后，不同的过程可调节环核苷酸的浓度。磷酸二酯酶（PDE）对环核苷酸的降解在调节环核苷酸浓度方面具有众所周知的作用。最近，人们已经认识到ATP结合盒（ABC）转运蛋白对cAMP的局部和整体调节都有贡献。最近的数据支持环核苷酸外流在肺动脉高压发病机制中的重要作用，因此表明抑制环核苷酸外流蛋白可能是预防和治疗肺动脉高压的一种有用策略。
