Schmidt C J, Ritter J K, Sonsalla P K, Hanson G R, Gibb J W
J Pharmacol Exp Ther. 1985 Jun;233(3):539-44.
Multiple administrations of high doses of methamphetamine to rats cause long-term depression of both dopamine and serotonin synthesis. Coadministration of the catecholamine synthesis inhibitor, alpha-methyl-p-tyrosine, antagonizes this effect of methamphetamine on both neurotransmitter systems. However, when catecholamine synthesis was maintained by the administration of L-dopa and the peripheral decarboxylase inhibitor R04-4602, alpha-methyl-p-tyrosine no longer prevented the effects of methamphetamine on either dopamine or serotonin synthesis. In addition, the administration of the specific dopamine uptake blocker, amfonelic acid, significantly attenuated the changes in the serotonin synthesizing enzyme, tryptophan hydroxylase, resulting from multiple high doses of methamphetamine. The ability of a single administration of methamphetamine to depress tryptophan hydroxylase was also dependent on catecholamine synthesis. These results suggest that dopamine plays an important role in the changes mediated by the administration of methamphetamine in both the dopaminergic and serotonergic systems.
给大鼠多次注射高剂量甲基苯丙胺会导致多巴胺和血清素合成的长期抑制。同时给予儿茶酚胺合成抑制剂α-甲基对酪氨酸可拮抗甲基苯丙胺对这两种神经递质系统的这种作用。然而，当通过给予左旋多巴和外周脱羧酶抑制剂R04 - 4602来维持儿茶酚胺合成时，α-甲基对酪氨酸不再能阻止甲基苯丙胺对多巴胺或血清素合成的影响。此外，给予特异性多巴胺摄取阻滞剂安非他明可显著减弱多次高剂量甲基苯丙胺导致的血清素合成酶色氨酸羟化酶的变化。单次注射甲基苯丙胺抑制色氨酸羟化酶的能力也依赖于儿茶酚胺合成。这些结果表明，多巴胺在甲基苯丙胺给药介导的多巴胺能和血清素能系统变化中起重要作用。
