博赛泼维诱导的阴茎异常勃起：CYP3A4 抑制和 α-肾上腺素能阻断作用：病例报告。
Priapism induced by boceprevir-CYP3A4 inhibition and α-adrenergic blockade: case report.
机构信息
Department of Pharmaceutical Sciences.
出版信息
Clin Infect Dis. 2014 Jan;58(1):e35-8. doi: 10.1093/cid/cit673. Epub 2013 Oct 2.
Abstract
A 44-year-old white man presented to the emergency department with a 3-day history of priapism requiring a surgically performed distal penile shunt. A drug-drug interaction is the suspected cause whereby CYP3A4 inhibition by boceprevir led to increased exposures of doxazosin, tamsulosin, and/or quetiapine, resulting in additional α-adrenergic blockade.
摘要
一位 44 岁的白人男性因阴茎异常勃起（持续 3 天，需要手术进行阴茎远端分流术）到急诊就诊。疑似药物相互作用导致，即博赛泼维抑制 CYP3A4，导致多沙唑嗪、坦索罗辛和/或喹硫平的暴露量增加，从而导致额外的α-肾上腺素能阻断。
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