Kindlin 点燃新火焰。
Kindlin ignites a new flame.
机构信息
UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE.
出版信息
Blood. 2013 Oct 3;122(14):2297-8. doi: 10.1182/blood-2013-08-519868.
Abstract
In this issue of , Pluskota et al have defined a completely novel role for Kindlin. This protein has been known for decades, but apparently it still has a few new tricks up its sleeve.
摘要
本期 杂志中，Pluskota 等人赋予了连接蛋白 Kindlin 一个全新的功能。这种蛋白人们已经研究了几十年，但显然它还有一些不为人知的新功能。
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本文引用的文献
1
Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism.Kindlin-2 通过网格蛋白依赖性机制控制血管内皮细胞表面 ADP/AMP 代谢酶的表达来调节止血。
Blood. 2013 Oct 3;122(14):2491-9. doi: 10.1182/blood-2013-04-497669. Epub 2013 Jul 29.
2
Congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophy.先天性斑驳病伴创伤性水疱形成和进行性皮肤萎缩。
Br J Dermatol. 1954 Mar;66(3):104-11. doi: 10.1111/j.1365-2133.1954.tb12598.x.
3
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome.Kindlin-1是秀丽隐杆线虫肌动蛋白-细胞外基质连接蛋白UNC-112的人类同源物，Kindlin-1的缺失会导致Kindler综合征。
Am J Hum Genet. 2003 Jul;73(1):174-87. doi: 10.1086/376609. Epub 2003 Jun 3.
4
Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome.在Kindler综合征中鉴定一个编码具有pleckstrin同源结构域的FERM家族蛋白的新基因中的突变。
Hum Mol Genet. 2003 Apr 15;12(8):925-35. doi: 10.1093/hmg/ddg097.
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