Jacob Florence, Vernaldi Saskia, Maekawa Takaki
Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research , Cologne , Germany ; Unité de Recherche en Génomique Végétale, Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, Université Evry Val d'Essone , Evry , France.
Front Immunol. 2013 Sep 25;4:297. doi: 10.3389/fimmu.2013.00297.
In plants and animals, nucleotide-binding domain and leucine-rich repeats (NLR)-containing proteins play pivotal roles in innate immunity. Despite their similar biological functions and protein architecture, comparative genome-wide analyses of NLRs and genes encoding NLR-like proteins suggest that plant and animal NLRs have independently arisen in evolution. Furthermore, the demonstration of interfamily transfer of plant NLR functions from their original species to phylogenetically distant species implies evolutionary conservation of the underlying immune principle across plant taxonomy. In this review we discuss plant NLR evolution and summarize recent insights into plant NLR-signaling mechanisms, which might constitute evolutionarily conserved NLR-mediated immune mechanisms.
在植物和动物中，含核苷酸结合结构域和富含亮氨酸重复序列（NLR）的蛋白质在先天免疫中发挥关键作用。尽管它们具有相似的生物学功能和蛋白质结构，但对NLR以及编码NLR样蛋白的基因进行全基因组比较分析表明，植物和动物的NLR在进化过程中是独立出现的。此外，植物NLR功能从其原始物种向系统发育上较远的物种进行家族间转移的证据表明，跨植物分类学存在潜在免疫原理的进化保守性。在这篇综述中，我们讨论了植物NLR的进化，并总结了对植物NLR信号传导机制的最新见解，这些机制可能构成进化上保守的NLR介导的免疫机制。
