Mudzinge Denise, Nyazika Tinashe Kenny, Chisango Tawanda Jonathan, Zhou Danai Tavonga
Department of Medical Laboratory Sciences, College of Health Sciences, University of Zimbabwe, P.O. Box A 178, Harare, Zimbabwe.
ISRN AIDS. 2013 Sep 4;2013:383214. doi: 10.1155/2013/383214. eCollection 2013.
Antiretroviral therapy inhibits HIV replication, maintains health, and preserves life. However, both antiretroviral therapy and HIV infection have been reported to have short- and long-term effects on bone metabolism. A cross-sectional study was performed to compare serum bone profiles in HIV positive patients on highly active antiretroviral therapy and compare them to therapy-naïve patients. Serum levels of calcium, magnesium, phosphate, and albumin were measured in 40 female participants on highly active antiretroviral therapy, recruited sequentially from Parirenyatwa Opportunistic Infections Clinic, Harare, Zimbabwe. The 40 women were matched for age with 40 antiretroviral therapy-naïve women. Magnesium, phosphate, and albumin levels were significantly higher in the therapy-naïve than in therapy-experienced patients. There was no statistically significant difference in calcium levels of the two groups of women. Evidence from this study suggests that highly active antiretroviral therapy lowers levels of magnesium, phosphate, and albumin but has no effect on levels of serum calcium.
抗逆转录病毒疗法可抑制艾滋病毒复制、维持健康并延长生命。然而，据报道，抗逆转录病毒疗法和艾滋病毒感染都会对骨代谢产生短期和长期影响。本研究进行了一项横断面研究，以比较接受高效抗逆转录病毒疗法的艾滋病毒阳性患者的血清骨谱，并将其与未接受过治疗的患者进行比较。在从津巴布韦哈拉雷的帕里伦亚瓦机会性感染诊所依次招募的40名接受高效抗逆转录病毒疗法的女性参与者中，测量了血清钙、镁、磷酸盐和白蛋白水平。这40名女性与40名未接受过抗逆转录病毒治疗的女性年龄匹配。未接受过治疗的患者的镁、磷酸盐和白蛋白水平显著高于有治疗经验的患者。两组女性的钙水平没有统计学上的显著差异。这项研究的证据表明，高效抗逆转录病毒疗法会降低镁、磷酸盐和白蛋白水平，但对血清钙水平没有影响。
