College of Chemistry, Beijing Normal University , Beijing, 100875, China.
Org Lett. 2013 Oct 18;15(20):5342-5. doi: 10.1021/ol402599f. Epub 2013 Oct 4.
Various aryl bromides or chlorides, including those bearing a free COOH, OH, CONHR, and SO2NHR group, coupled with aryl magnesium or lithium reagents in the presence of 7.5 mol % CoCl2/15 mol % PBu3 and substoichiometric Ti(OEt)4 (40 mol % to ArM) at room temperature in high yields with high chemo- and regioslectivity. This simple reaction represents the first example of Co/Ti cooperative catalysis which plays a key role in suppressing undesired homocouplings.
各种芳基溴化物或氯化物，包括带有游离 COOH、OH、CONHR 和 SO2NHR 基团的芳基溴化物或氯化物，在 7.5 mol% CoCl2/15 mol% PBu3 和亚化学计量的 Ti(OEt)4（40 mol%至 ArM）存在下，与芳基镁或锂试剂在室温下以高产率和高化学选择性和区域选择性偶联。这个简单的反应代表了 Co/Ti 协同催化的第一个例子，它在抑制不需要的同偶联中起着关键作用。
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