Manolikakes Georg, Muñoz Hernandez Carmen, Schade Matthias A, Metzger Albrecht, Knochel Paul
Department Chemie and Biochemie, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany.
J Org Chem. 2008 Nov 7;73(21):8422-36. doi: 10.1021/jo8015852. Epub 2008 Oct 4.
A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups. A similar nickel-catalyzed reaction is described. The relative kinetic basicity of organozinc compounds as well as their stability toward acidic protons is also described.
使用Pd(OAc)₂（1 mol%）和S-Phos（2 mol%）作为催化剂，无需保护基团，一系列多官能芳基、杂芳基、烷基和苄基锌试剂与带有酸性NH或OH质子的不饱和芳基卤化物发生偶联反应。还描述了类似的镍催化反应。同时也描述了有机锌化合物的相对动力学碱性及其对酸性质子的稳定性。
