遗传的 mtDNA 异质性：衰老的基线？
Hereditary mtDNA heteroplasmy: a baseline for aging?
机构信息
Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK.
出版信息
Cell Metab. 2013 Oct 1;18(4):463-4. doi: 10.1016/j.cmet.2013.09.015.
PMID:24093673
Abstract
Do mtDNA mutations contribute to the aging process, or are they innocent bystanders? Ross et al. (2013) show that inherited mtDNA point mutations lead to a premature aging phenotype in mice and "prime" the maternal lineage, interacting with subsequent somatic mutations to cause brain malformations and shorten lifespan.
摘要
线粒体 DNA 突变是否会导致衰老过程，还是它们只是无辜的旁观者？罗斯等人（2013 年）表明，遗传的线粒体 DNA 点突变导致小鼠出现早衰表型，并“启动”母系，与随后的体细胞突变相互作用导致大脑畸形并缩短寿命。
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