Organic Chemistry Division, and Center for Materials Characterization, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune - 411008, India.
Org Lett. 2013 Oct 18;15(20):5202-5. doi: 10.1021/ol4026155. Epub 2013 Oct 4.
N-Heterocyclic carbene (NHC)-catalyzed highly enantioselective lactonization of modified enals with enolizable aldehydes, proceeding via the α,β-unsaturated acylazolium intermediates, is reported. The reaction results in the asymmetric synthesis of synthetically important 4,5-disubstituted dihydropyranones.
报道了 N-杂环卡宾（NHC）催化的经修饰的烯醛与可烯醇化的醛的高对映选择性内酯化反应，该反应通过α,β-不饱和酰基氮鎓中间体进行。该反应导致了具有合成重要性的 4,5-二取代二氢吡喃酮的不对称合成。
