Herrmann F, Dörken B, Ludwig W D, Schwarting R
Leuk Res. 1985;9(5):529-36. doi: 10.1016/0145-2126(85)90132-8.
The neoplastic cells from 14 cases of hairy-cell leukemia were investigated in order to determine their membrane phenotype on the basis of their reactivity with a large panel of B-, T-, myeloid/monocytic- and non-lineage restricted monoclonal antibodies. The data were compared to those from monoclonal antibody studies on phorbol-ester (TPA) induced cells from 10 patients with B-type chronic lymphocytic leukemia. The study has so far revealed further evidence for the B-cell nature of hairy-cells leukemia and demonstrates a developmental link between the two cell types, suggesting that hairy-cells represent a more advanced differentiation stage along the B-cell lineage.
为了根据14例毛细胞白血病的肿瘤细胞与大量B细胞、T细胞、髓系/单核细胞系及非谱系限制性单克隆抗体的反应性来确定其膜表型，对这些细胞进行了研究。将这些数据与10例B型慢性淋巴细胞白血病患者经佛波酯（TPA）诱导的细胞的单克隆抗体研究数据进行了比较。该研究迄今已揭示了毛细胞白血病B细胞性质的进一步证据，并证明了这两种细胞类型之间的发育联系，表明毛细胞代表了B细胞谱系中一个更高级的分化阶段。
