内体中的胃酸反流：将信号失调与神经发育障碍联系起来。
Acid indigestion in the endosome: linking signaling dysregulation to neurodevelopmental disorders.
机构信息
University of Virginia, Department of Neuroscience, 409 Lane Road, Charlottesville, VA 22908, USA.
出版信息
Neuron. 2013 Oct 2;80(1):4-6. doi: 10.1016/j.neuron.2013.09.018.
PMID:24094097
Abstract
The sodium-proton exchanger NHE6 contributes to proper endosomal acidification. NHE6 mutations are also linked to autism-related disorders. In this issue of Neuron, using NHE6-knockout mice, Ouyang et al. (2013) uncover how dysregulation of endosomal pH leads to disturbances in BDNF signaling and neuronal morphogenesis defects.
摘要
钠-质子交换器 NHE6 有助于内体的正常酸化。NHE6 突变也与自闭症相关疾病有关。在本期《神经元》杂志中，Ouyang 等人（2013）使用 NHE6 敲除小鼠揭示了内体 pH 失调如何导致 BDNF 信号转导紊乱和神经元形态发生缺陷。
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