Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China.
Mater Sci Eng C Mater Biol Appl. 2013 Dec 1;33(8):4562-7. doi: 10.1016/j.msec.2013.07.009. Epub 2013 Jul 18.
Drug loading capacity is an important property for an ideal drug delivery system. However, the drug loading capacity of prepared pH-sensitive polymeric nanoparticles is usually low. To overcome this drawback, the electrospray method was used to prepare Eudragit L 100-55 nanoparticles with high drug loading capacity in one step. Omeprazole was selected as the model drug. The maximum loading capacity of nanoparticles was 43.21% by changing the mass ratio of drug to polymer, and the entrapment efficiency was nearly 100%. The prepared nanoparticle showed spherical or ellipsoidal morphology and the average diameter was about 300 nm. The pH-sensitive nanoparticle displayed pH-dependent release in vitro. In addition, a slight cytotoxicity was detected in the cytotoxicity study. The results indicated that electrospray is an easy, rapid and efficient technique for the preparation of high-loading pH-sensitive polymeric nanoparticles, and the pH-sensitive nanoparticle is a promising carrier for oral drug delivery.
载药量是理想药物输送系统的一个重要性质。然而，所制备的 pH 敏感聚合物纳米粒的载药量通常较低。为了克服这一缺点，采用静电喷雾法一步法制备载药量高的 Eudragit L 100-55 纳米粒。以奥美拉唑为模型药物。通过改变药物与聚合物的质量比，纳米粒的最大载药量可达 43.21%，包封率接近 100%。所制备的纳米粒呈球形或椭圆形，平均直径约为 300nm。该 pH 敏感纳米粒在体外表现出 pH 依赖性释放。此外，在细胞毒性研究中检测到轻微的细胞毒性。结果表明，静电喷雾是一种用于制备高载药量 pH 敏感聚合物纳米粒的简便、快速、高效的技术，pH 敏感纳米粒是口服药物输送的一种有前途的载体。
