Faculty of Science, Department of Chemistry, University of Guilan, Namjoo Street, PO Box, 1914, Rasht, Iran.
Mater Sci Eng C Mater Biol Appl. 2013 Dec 1;33(8):4876-83. doi: 10.1016/j.msec.2013.08.002. Epub 2013 Aug 13.
In this work, using of amine-functionalized TiO2/multi-walled carbon nanotubes (NH2-TiO2-MWCNTs) nanocomposite for modification of glassy carbon electrode (GCE) was investigated. The nanocomposite was characterized by Fourier transformed infrared spectroscopy, transmission electron microscopy and scanning electron microscopy. The efficiency of modified electrode for electrocatalytic the oxidation of olanzapine was studied by cyclic voltammetry, square wave voltammetry and chronoamperometry. The electrochemical measurements were carried out in phosphate-buffered solution (PBS, pH 5.0). The NH2-TiO2-MWCNTs/GCE provided high surface area and more sensitive performance. The charge transfer coefficient (α) and the apparent charge transfer rate constant (k(s)) were calculated to be equal to 0.42 and 0.173 s(-1), respectively. The square wave voltammetry exhibited two linear dynamic ranges and a detection limit of 0.09 μM of olanzapine. In addition, the modified electrode was employed for the determination of olanzapine in pharmaceutical and human blood serum samples in order to illustrate the applicability of proposed method.
在这项工作中，研究了用胺功能化 TiO2/多壁碳纳米管（NH2-TiO2-MWCNTs）纳米复合材料修饰玻碳电极（GCE）。通过傅里叶变换红外光谱、透射电子显微镜和扫描电子显微镜对纳米复合材料进行了表征。通过循环伏安法、方波伏安法和计时安培法研究了修饰电极对奥氮平氧化的电催化效率。电化学测量在磷酸盐缓冲溶液（PBS，pH 5.0）中进行。NH2-TiO2-MWCNTs/GCE 提供了高表面积和更灵敏的性能。计算得到的转移系数（α）和表观转移速率常数（k(s)）分别为 0.42 和 0.173 s(-1)。方波伏安法显示了两个线性动态范围和奥氮平的检测限为 0.09 μM。此外，该修饰电极还用于测定药物和人血清样品中的奥氮平，以说明所提出方法的适用性。
