Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China; Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.
Eur J Radiol. 2013 Dec;82(12):e894-900. doi: 10.1016/j.ejrad.2013.08.023. Epub 2013 Sep 11.
To evaluate dynamic volume perfusion CT (dVPCT) tumor baseline characteristics of three different subtypes of lung cancer in untreated patients.
173 consecutive patients (131 men, 42 women; mean age 61 ± 10 years) with newly diagnosed lung cancer underwent dVPCT prior to biopsy. Tumor permeability, blood flow (BF), blood volume (BV) and mean transit time (MTT) were quantitatively assessed as well as tumor diameter and volume. Tumor subtypes were histologically determined and compared concerning their dVPCT results. dVPCT results were correlated to tumor diameter and volume.
Histology revealed adenocarcinoma in 88, squamous cell carcinoma in 54 and small cell lung cancer (SCLC) in 31 patients. Tumor permeability was significantly differing between adenocarcinoma, squamous cell carcinoma and SCLC (all p<0.05). Tumor BF and BV were higher in adenocarcinomathan in SCLC (p = 0.001 and p=0.0002 respectively). BV was also higher in squamous cell carcinoma compared to SCLC (p = 0.01). MTT was not differing between tumor subtypes. Regarding all tumors, tumor diameter did not correlate with any of the dVPCT parameters, whereas tumor volume was negatively associated with permeability, BF and BV (r = -0.22, -0.24, -0.24, all p<0.05). In squamous cell carcinoma, tumor diameter und volume correlated with BV (r = 0.53 and r = -0.40, all p<0.05). In SCLC, tumor diameter und volume correlated with MTT (r = 0.46 and r = 0.39, all p<0.05). In adenocarcinoma, no association between morphological and functional tumor characteristics was observed.
dVPCT parameters are only partially related to tumor diameter and volume and are significantly differing between lung cancer subtypes.
评估未经治疗的患者中三种不同类型肺癌的动态容积灌注 CT（dVPCT）肿瘤基线特征。
173 例新诊断为肺癌的连续患者（男 131 例，女 42 例；平均年龄 61 ± 10 岁）在活检前进行了 dVPCT。定量评估了肿瘤通透性、血流量（BF）、血容量（BV）和平均通过时间（MTT），以及肿瘤直径和体积。通过组织学确定肿瘤亚型，并比较它们的 dVPCT 结果。dVPCT 结果与肿瘤直径和体积相关。
组织学显示腺癌 88 例，鳞癌 54 例，小细胞肺癌（SCLC）31 例。腺癌、鳞癌和 SCLC 之间肿瘤通透性差异显著（均 p<0.05）。腺癌的肿瘤 BF 和 BV 均高于 SCLC（p=0.001 和 p=0.0002）。与 SCLC 相比，鳞癌的 BV 也更高（p=0.01）。MTT 在肿瘤亚型之间无差异。对于所有肿瘤，肿瘤直径与任何 dVPCT 参数均无相关性，而肿瘤体积与通透性、BF 和 BV 呈负相关（r=-0.22、-0.24、-0.24，均 p<0.05）。在鳞癌中，肿瘤直径和体积与 BV 相关（r=0.53 和 r=-0.40，均 p<0.05）。在 SCLC 中，肿瘤直径和体积与 MTT 相关（r=0.46 和 r=0.39，均 p<0.05）。在腺癌中，形态和功能肿瘤特征之间没有关联。
dVPCT 参数仅部分与肿瘤直径和体积相关，并且在肺癌亚型之间存在显著差异。
