Department of Surgery, University of Pittsburgh, United States.
Nitric Oxide. 2013 Nov 30;35:175-85. doi: 10.1016/j.niox.2013.09.004. Epub 2013 Oct 1.
Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.
一氧化氮（NO）是一种细胞内和细胞间的信号分子，可调节血管扩张、神经元传递、心脏收缩、免疫调节以及干细胞分化和增殖。NO 在心血管系统中起着重要的保护作用。NO 抑制平滑肌细胞增殖和迁移；促进内皮细胞增殖和迁移，抑制细胞凋亡；抑制血小板聚集；防止血小板、白细胞和单核细胞黏附于内皮细胞。NO 对机械或免疫损伤血管内膜增生的发展具有抑制作用。旨在提高 NO 生物利用度或协助局部递呈 NO 的新治疗方法可能有助于心血管疾病患者。
