Balázs Csaba, Rácz Károly
Budai Endokrin Központ Budapest Ostrom u. 16. 1015.
Orv Hetil. 2013 Oct 13;154(41):1628-35. doi: 10.1556/OH.2013.29723.
Oxygen derived free radicals, generated by a number of cellular reactions, include superoxide anion, hydrogen peroxide and hydroxyl radicals. They exert their cytotoxic effects mainly via peroxidation of the cell membrane resulting in the loss of membrane integrity. The essential trace element, selenium exerts complex effects on the endocrine systems, partly due to its antioxidant capacity. Well-characterized selenoproteins include iodothyronine deiodinases, glutathione peroxidases and thioredoxin reductases involved in thyroid hormone metabolism and protection from oxidative damage. The value of selenium supplementation in autoimmune thyroid disorders has been investigated and most studies confirmed the beneficial effect of selenium supplementation in Hashimoto's and Graves's diseases. Recently, selenium proved to be effective in mild inflammatory orbitopathy. There are a number of reports about the effect of selenium in diabetes mellitus, but the data are controversial as both insulin-like and diabetes-inducing effects of selenium have been described. Selenium was successfully used in both female and male infertility of autoimmune origin.
由多种细胞反应产生的氧衍生自由基包括超氧阴离子、过氧化氢和羟基自由基。它们主要通过细胞膜的过氧化作用发挥细胞毒性作用，导致膜完整性丧失。必需微量元素硒对内分泌系统有复杂的影响，部分原因是其抗氧化能力。已明确的硒蛋白包括参与甲状腺激素代谢和抗氧化损伤的碘甲状腺原氨酸脱碘酶、谷胱甘肽过氧化物酶和硫氧还蛋白还原酶。已对自身免疫性甲状腺疾病补充硒的价值进行了研究，大多数研究证实补充硒对桥本氏病和格雷夫斯病有有益作用。最近发现硒对轻度炎性眼眶病有效。有许多关于硒对糖尿病影响的报道，但数据存在争议，因为已描述了硒的胰岛素样作用和致糖尿病作用。硒已成功用于自身免疫性起源的女性和男性不孕症治疗。
