Po-Jen Liu, Department of Otolaryngology and Nutrition and Naturopathic center, Cheng-Ching Hospital, Taiwan Boulevard, Taichung 407, Taiwan, Republic of China.
J Nutr Health Aging. 2013;17(8):639-44. doi: 10.1007/s12603-013-0023-x.
Obstructive sleep apnea (OSA) is associated with increased oxidative stress. Certain essential trace minerals have shown to play an important role in the maintenance of redox homeostasis. We determined the concentrations of trace minerals in OSA patients and assessed their relationships to OSA severity as indicated by the apnea/ hypopnea index (AHI).
We enrolled 44 patients with newly diagnosed mild to moderate OSA and 20 without OSA. The following parameters were measured: polysomnographic values of nocturnal sleep; plasma trace minerals zinc (Zn), copper (Cu), iron (Fe), and erythrocyte selenium (Se); oxidative stress status; and plasma high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α).
Compared to controls matched for age, gender, and body mass index, OSA patients had lower concentrations of plasma Zn and erythrocyte Se and higher plasma concentrations of Cu and Fe. OSA patients had significantly higher plasma concentrations of hs-CRP, TNF-α, and malondialdehyde (MDA), and lower erythrocyte antioxidant enzyme glutathione peroxidase (GPx) and superoxide dismutase activities. Significant differences in all the above parameters were also found in patients with moderate OSA compared to those with mild OSA. Furthermore, AHI values correlated significantly with neck circumference, GPx activity, and MDA, hs-CRP, and TNF-α concentrations in OSA patients. AHI values were also negatively associated with concentrations of plasma Zn and erythrocyte Se, but were positively linked to plasma concentrations of Fe and Cu.
Abnormal concentrations of these trace minerals may reflect oxidative damage and inflammatory response, thus increasing the severity of OSA.
阻塞性睡眠呼吸暂停（OSA）与氧化应激增加有关。某些必需的痕量矿物质已被证明在维持氧化还原稳态方面发挥着重要作用。我们测定了 OSA 患者的痕量矿物质浓度，并评估了它们与呼吸暂停/低通气指数（AHI）所示 OSA 严重程度的关系。
我们纳入了 44 例新诊断的轻至中度 OSA 患者和 20 例无 OSA 患者。测量了以下参数：夜间睡眠多导睡眠图值；血浆痕量矿物质锌（Zn）、铜（Cu）、铁（Fe）和红细胞硒（Se）；氧化应激状态；以及血浆高敏 C 反应蛋白（hs-CRP）和肿瘤坏死因子-α（TNF-α）。
与年龄、性别和体重指数匹配的对照组相比，OSA 患者的血浆 Zn 和红细胞 Se 浓度较低，血浆 Cu 和 Fe 浓度较高。OSA 患者的血浆 hs-CRP、TNF-α 和丙二醛（MDA）浓度显著升高，红细胞抗氧化酶谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶活性显著降低。与轻度 OSA 患者相比，中度 OSA 患者的所有上述参数也存在显著差异。此外，AHI 值与 OSA 患者的颈围、GPx 活性以及 MDA、hs-CRP 和 TNF-α 浓度显著相关。AHI 值与血浆 Zn 和红细胞 Se 浓度呈负相关，与血浆 Fe 和 Cu 浓度呈正相关。
这些痕量矿物质浓度的异常可能反映了氧化损伤和炎症反应，从而增加了 OSA 的严重程度。
